The arrows threw me off for a little while with my 75+ (same placement as 96). Frequent use and maybe some extra time practicing and I think anyone can adjust quickly. Probably best to stay away from a full keyboard while adjusting though.
On the topic of subs, a user on another forum has compiled a handy spreadysheet:
https://docs.google.com/spreadsheets/d/1dU5OOnf3nVgctJszmfyBjaxK69dkXte6ZL6anVTW2_M/edit#gid=834598950
Have a default or recommended baseline setup and let users flip things on or off and everyone (or close enough) would be content. The majority seem to find the "convenience" of having updates, features, or whatever else forced upon them to be preferable.